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COMputational tool for the assessment and substitution of Biocidal Active substanceS of Ecotoxicological concern


Promotion of the sustainable use of biocidal active substances from a life cycle perspective.
Source of funds:
Biocides are used in the treatment of damaging biological growth. However, not only do they kill pathogens, they also kill non-pathogens, meaning they may have undesirable side effects harming human health and/or the environment.

For instance, in the service life phase, when released to the different environmental compartments (soil, surface waters, groundwater and air, depending on the actual use of the biocidal product), the active substances undergo a series of degradation reactions generating metabolites, transformation or reaction products that might significantly differ from the parent compounds in terms of their associated toxicity.

Considering the impact of active substances used in biocidal products and the metabolites, degradation and transformation products released to the environment during the application and service life phases, novel tools are necessary for the identification and substitution of biocides of ecotoxicological concern under an integrated life cycle perspective.

The use of non-animal alternative test methods has been foreseen in the Biocides Product Regulation, Regulation (EU) 258/2012 (BPR). The widespread use of non-testing methods (NTM) would help SMEs identifying, amongst other, the so called metabolites of ecotoxicological concern whereas facilitating the registering of biocidal active substances within the BPR and reducing animal testing.

The main target of the LIFE-COMBASE Project is to promote the sustainable use of biocidal active substances from a life cycle perspective. To this end, an on-line information system based on the combination of evidence based decision support systems (EBDSS) and proven computational toxicology modelling approaches will be implemented.

INKOA SISTEMAS, Coordinating Beneficiary, focuses its work on the conceptualization of the COMBASE Tool and programming, along with project strategical coordination and management, dissemination and monitoring actions.

INIA and XNB are responsible for the compilation of the ecotoxicological information and for the experimental validation of the models.

ITENE will develop the COMBASE APP for mobile devices and implement the E-learning platform for the sustainable use of biocides. ProtoQSAR and IRFMN will work closely for the optimization of the models and for making them available through already existing platforms (VEGA). All partners will carry out dissemination actions and collaborate so that the results of the project are undertaken by the relevant stakeholders be it of industrial nature or regulatory bodies.

COMBASE Project is co-financed by the Life+ Environment Policy & Governance Programme.  LIFE15 ENV/ES/416

Contribution:  94.820,00€
Project ID: ENV/ES/000416
Comisión Europea - Life

Comisión Europea - Life